The role of microRNAs in breast cancer Essay Example | Topics and Well Written Essays - 1750 words

The role of microRNAs in breast cancer - Essay Example Below is a description of the effect of miRNAs in breast cancer metastasis, treatment and cause. Regulation on Cancer Causing Proteins According to Yamashita and others, mis-expressions or mutations in miRNA have been associated with different types of human cancers. The loss-or-gain-of function of some miRNAs has also been found to contribute to tumorigenesis and epithelial cellular transformation of the breast. Research has also revealed that profiling of miRNA expression shows that different molecular subtypes in breast cancer have different expressions of miRNAs (Yamashita et al, n.d., p. 331). ER? is responsible for breast cancer. There are two types of ER? related breast cancers. There are ER?-negative and ER?-positive breast cancers. Most primary breast cancers express ER? with an approximate value of 70%. ER?-positive breast cancers have been found to respond positively to endocrine therapy. This could be because of the role of ER? in the endocrine system. ER? is necessary fo r estrogen-dependent growth. It affects the response to endocrine therapy among women with ER?-positive breast cancers depending on its level of expression. ... 331). The Roles of miRNAs in Cellular Processing There are various cellular processes in which miRNAs are involved. These include development of skeletal and heart muscles, and establishment and maintenance of cell lineage. The miRNAs have the ability to express specific tissue, which has been, observed in insulin secretion, proliferation, hematopoiesis, adepocyte development, apoptosis, and brain pattering. Because of these roles and involvement in diverse cellular functions, miRNAs’ function and expression dysregulation has the potential to cause diseases. This has been observed in Tourette’s syndrome, fragile X syndrome, and from recent research studies, associated with cancer development and progression (Kayani, Kayani, Malik & Faryal, 2011, p. 3175). Bachour and Bennett (2011) also note that miRNAs are involved in regulation of apoptosis, proliferation and differentiation, and have the ability to directly obstruct stability and translation of specific gene transcri pts that they target and cause cell physiology disorder. In breast cancer, for example, miRNAs have been found to be involved in the dysregulation of tumor suppressor genes and oncogenes, causing progression of breast cancer (Bachour & Bennett, 2011; Liu et al, 2011). MiRNAs are also found in regulation of cell development and cell cycle. This characteristic places them in the best place for exploring anticancer treatments. Altered miRNA signatures cause breast cancer metastasis and development. This has been identified through the study of the effect of the loss of tumour suppressor miRNAs such as miR-31, miR-203, miR-30a, miR-34a, miR-200s, miR-205, miR-342, miR-125s, miR-206, and let-7s, or the over-expression of oncogenic miRNA such as miR-21, miR-155, miR-222, miR-10b,

Critically examine the claim that THE key to being an innovative Essay

Critically examine the claim that THE key to being an innovative organisation is R & D more expenditure equals more innovation - Essay Example e constantly engaging in research and development in order to come up with new approaches of doing things, design new products for the market, acquire new market for the products and expand business capacity to meet the current and future market demand (United Nations, 2012, p. 11). Innovation is a role of all workers in an organization. In order for an organization to be competitive in the market, it has to promote and nurture a culture of creativity among the workers and provide the necessary resources to support innovation. The organizations should have the capacity to recognize the need for innovation and support the ideas that can lead to competence of the organizations. The ideas could be small or big and they follow a particular process. Innovation requires resources including time and finances (Mazzucato, 2013, p. 84). Organizations must be willing to devote the required resources in order to achieve the expected goals. They should engage in research and development in order to explore various approaches to improving products, processes or market and implement the new ideas as their core competences for future growth. Innovation may imply the organization developed their knowledge or acquired the knowledge from another organization. Irrespective of the method, the business, used to innovate, the organization has to incur some cost in order to gain that knowledge. Innovation is an entrepreneurial role of creating a new product or processes for the market. Entrepreneurs earn profit from their innovations by establishing a monopoly (Unit 1: Lecture 1). They acquire patent rights to limit other competitors from producing and selling similar products in the same market. However, the entrepreneurs cannot prohibit the entry of competitors in the market for a long. Competitors start offering similar products with those of the entrepreneur thus limiting the potential for expansion of the business. The entrepreneurs should develop a culture of innovation in order to

Altmans Z-Score Research Paper Example | Topics and Well Written Essays - 500 words

Altmans Z-Score - Research Paper Example Altman’s Z-Score This is the same treatment used on the financial trends. The application of the Altman’s Z-Score rationale in the banking sector is based on the assumption that the loan applicants will experience a rejection in their loan status. This is a decline from the loan application. The loan applicants may also experience a thorough scrutiny in case the value observed from the Z-Score falls below the minimal critical value. The applicability of the model goes to private companies, emerging markets and to non-manufacturing firms. The discriminant resulting function illustrates itself by us of the formulae below Z=1.2X1+1.4X2+2.3X3+0.64+0.999X5 If the computation reveals a lower value e.g. of 1.81, it can be inferred to be a failed firm. An upper value of 2.99 is a successful firm and will therefore be more attractive for investment. The value of scores that forms below the successful and the failing firm forms the ignorance zone. The predictability of any model depends upon the standard deviation of the group being small. The ideology behind the multiple discriminant analysis engages on principles set to enable maximization of the group between differences while at the same time minimizing the group within differences. The process itself involves variables that can be inclusive or exclusive on an analytical criterion. The determination of the result must involve a set of guidelines that involve the observation of the data giving importance as well as the determination of the contribution. This contribution is geared towards independent variable.

Sustainability within National Parks Essay Example | Topics and Well Written Essays - 3500 words

Sustainability within National Parks - Essay Example In relation to the shifts in the industry trends, the overall events management industry is striving towards creating all round diversity in the meeting and events profession. This particular industry largely values the scope of diversifying the events management along with tourism industry in a well defined manner (Marvell, 2006). In this respect, a professional proposal document enumerating current thinking on ‘green’ issues in relation to the MICE sector will be analysed upon. In this regard, the aforesaid document will help in establishing a clear cut idea pertaining to the credibility as a conference organizer. All of these aspects will be discussed in the form of a literature review in order to derive an in-depth knowledge about the subject matter. Literature Review and Overview of Current Thinking on ‘Green’ Issues In Relation to MICE Sector As a conference organizer, the primary stress is needed to be laid upon the aspects associated with the depicti on of a clear and precise plan concerning current thinking on ‘green’ issues. Creation of travel incentives long with additional options is considered to be very important nowadays. Additionally, options representing greenness are becoming a modern trend in the contemporary tourism industry. This facet is proving to create a great deal of appeal to all those travellers who are environment conscious. Moreover, this facet is proving to provide a considerable extent of support along with growth to this particular industry. This concept is said to gain all round importance in South Africa as their MICE industry tries to deal with a slow increase in business tourism. This slow and steady developmental phase is responsible for creating all round importance about the concept of green to a very large extent. Similar to this subject, Green Party of Aotearoa New Zealand provided reports that signify the importance of green by a considerable extent. The reports suggested that with the induction of green it will lead to growth in knowledge which includes basic science along with technological dimensions. All these aspects can very well provide corresponding results that can lead to the development of a sustainable economy. Other broad significances of this initiative can lead to shrinking of waste materials, pollution along with overuse of different types of scarce resources. If all of these aspects are fulfilled then it will lead to even greater amount of benefits. It will eventually lead to smart business processes, good education along with efficient work in diversified fields. Thinking green will ensure proper control over economic aspects as well which can result in bringing a lot of cohesion as well while trading with different countries located around the world. Thus, the

Tsunami Analysis Essay Example | Topics and Well Written Essays - 1500 words

Tsunami Analysis - Essay Example The process of research is the backbone to the preparation of any piece of academic writing. Research involves the processes of acknowledging sources, avoiding plagiarism, in-text referencing and preparation of references. According to an article from the University of Canberra, many students write their academic papers based on the ideas of other writers or authors. As a result, it is proper for these students to acknowledge sources since it gives credibility to the source or piece of writing being prepared. The acknowledgement of sources helps in supporting research conducted by the student or researcher. The article further clarifies that acknowledgement of sources gives authority to a piece of writing while at the same time it helps in avoiding plagiarism. Plagiarism is a crime that many students usually commit knowingly and unknowingly which can be avoided by properly acknowledging sources (Harbord, 2007). Finally the article gives examples of pieces of writing that could be con sidered as academic. Academic writing assignments include dissertations, literature reviews and annotated bibliographies which are commonly written by students. Dissertations can be short or long pieces of writing while literature reviews is a piece of writing that gives an overview of a research question or issue. Annotated bibliographies are also used in summarizing sources listed in the reference list and they are effective is shading light into the general idea expressed by the writer (Harbord, 2007). Different academic writing styles make use of citation styles such as APA, MLA and Harvard in acknowledging the sources from different authors. Generally, the article was important in giving... The paper tells that Asian Tsunami of the year 2004 did not spear the environment since several coastlands where the coastlines were redrawn leading to change in coastlines. For instance, the Andaman and Nicobar islands were severely destroyed by the Asian tsunami. Sea creatures were not speared in the aftermath of the tsunami as many sea animals were killed especially around the epicentre of the undersea earthquake. Once the ocean moved a lot of damage and catastrophe were noticed within a short period of time. The devastation led was noticed by the International community and many countries came along to the aid of the affected countries and people. Australia was one of the countries that came to the aid of the affected regions and people in the Asian region. Several Australian tourists who were holidaying in the region were evacuated with the help of the Australian governments. The tsunami was massive and it reached the coast of Australia but it did not cause a lot of damage. Aust ralia, the United States of America and several European countries mopped up funds and personnel aid to the Asian countries hit by the tsunami. Many people were displaced by the tsunami and they were in dire need of help thus help was extended to them. Most of these internally displaced people (IDP’s) lacked food, shelter, water and health services hence international community in conjunction with aid agencies such as the Red Cross and Medicine San Frontiers.

Government Essay Example | Topics and Well Written Essays - 1000 words - 8

Government - Essay Example We have always believed that the Democratic Party government is the only one that could take USA back to where it used to be and make it even better (Lantis 43). Constitutionally, parties represent people. People usually have views and opinions for what their government should represent. In the paper, I will be discussing some of the major policies presented by the Democratic Party government to its citizens. Democratic Party has good economic policies which will be able to create a positive economic growth for the country. First of all, DP had hoped to introduce to reduce taxes on essential goods and even basic salaries of people (Lantis 67). The main reason for this was to ensure that people remained with more money instead of the government taking most of it. Disposable income is basically what gives people purchasing power, and ability to invests and make certain goods and services. The party argues that high disposable income equals to a country’s GDP. Another way which USA was going to boost the economy was through attracting investors through having good policies. The government hence introduced low taxes on foreigners and some cases, provided tax free periods so as to attract more foreign people to invest in their country (Lantis 73). I believe the policy has been effective since the county managed to pull from the economic depression of 2008-2010 and seems to be recording a positive movement. I have confidence in the party, that if given another 20 years, the USA economy will be very powerful. I have personally appreciated this policy when my parents who got unemployed back in 2010, got their jobs back in the respective companies. Another great policy which the Democratic Party had in place was the move to increase job opportunities. USA had been having a problem of unemployment ever since its economy plunged in 2008. Many people lost their careers and livelihood. In their policy, they had

A Deadly Duel in the Name of Preserving Burr and Hamilton Honour Research Paper - 79

A Deadly Duel in the Name of Preserving Burr and Hamilton Honour - Research Paper Example The author intended this document for historians and the entire public since the duel was shrouded in mystery. Even to date, historians are never too sure as to why the two men duelled. Therefore, through this document, the author attempts to solve the mystery for historians and other concerned parties. The document makes it clear that the duel was long overdue. This is because Burr and Hamilton had a long-standing political, military and personal rivalry. The only way to solve the rivalry was to eliminate either of them. The author of the document seems to be striving for credibility and authenticity in presenting his ideas. He says: â€Å"Matthews L. Davis, Burr’s close friend, gives an eye-witness account of the encounter, in which Hamilton was mortally wounded.† (p143). The author, therefore, wished to draw confidence from the readers so as to help them solve the Burr-Hamilton puzzle once and for all. The author does so, considering the shock waves that the duel sent across America’s political and social landscape. Moreover, it is possible that having been a close ally to Burr, Davis may have wanted to set the record straight to avoid suspicion for foul play in the debacle. He may, therefore, be out to clear his conscience. The second primary source, Duel as Politics by Freeman corroborates the evidence in the first document. It states: â€Å" ‘General Hamilton was shot by Colonel Burr in a duel this morning. The General is said to be mortally wounded.’† (Freeman 47). This quotation appeared in a bulletin in 1804, reporting the death of Hamilton in the fatal duel.